Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma
نویسندگان
چکیده
منابع مشابه
Mogamulizumab Treatment in a Hemodialysis Patient with Adult T-Cell Leukemia/Lymphoma
Mari Yoshihara1, Yasushi Kubota1,2, Makoto Fukuda3, Tomoya Kishi3, Yuji Ikeda3, Shinya Kimura1 1Saga University Faculty of Medicine, Department of Internal Medicine, Division of Hematology Respiratory Medicine, and Oncology, Saga, Japan 2Saga University Faculty of Medicine Hospital, Department of Transfusion Medicine, Saga, Japan 3Saga University Faculty of Medicine, Department of Internal Medi...
متن کاملA case of post-mogamulizumab relapse of acute-type adult T-cell leukemia/lymphoma successfully treated with mogamulizumab and etoposide.
A 70-year-old man presented to us with the chief complaints of a generalized rash and a mass in the right clavicular region that he first noticed in the year 2012. Biopsy of the mass led to the diagnosis of cutaneous nodular mass-type adult T-cell leukemia/lymphoma (ATLL) in March 2013. Phototherapy was started, and the symptoms improved temporarily. However, in late June 2013, the serum lactat...
متن کاملMogamulizumab for relapsed adult T‐cell leukemia–lymphoma: Updated follow‐up analysis of phase I and II studies
The present study sought to elucidate the prognosis of adult T-cell leukemia-lymphoma (ATL) patients receiving mogamulizumab, a defucosylated anti-CCR4 monoclonal antibody. Progression-free survival (PFS) and overall survival (OS) of ATL patients enrolled in two studies are herein updated, namely NCT00355472 (phase I study of mogamulizumab in relapsed patients with ATL and peripheral T-cell lym...
متن کاملStevens-Johnson Syndrome Associated with Mogamulizumab-induced Deficiency of Regulatory T cells in an Adult T-cell Leukaemia Patient.
Stevens-Johnson syndrome (SJS) is a rare but extremely severe drug-induced eruption characterised by widespread necrosis or apoptosis of the epidermis (1). The main causal factor for SJS is an aberrant activation of CD8 T cells. Although the dysfunction of the regulatory T cells (Treg) is considered a possible cause of excess CD8 T cells activation (2), the actual significance of Tregs in vivo ...
متن کامل[Treatment of adult T-cell leukemia].
The treatment strategy for adult T-cell leukemia has not been established. CHOP derived combination chemotherapy protocols such as VEPA and VEPAM have failed to yield high complete remission rates and long survivals. Second or third generation combination chemotherapy regimens using alternative non-cross resistant drugs also have not achieved satisfactory results. A new multi-institutional tria...
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ژورنال
عنوان ژورنال: Blood and Lymphatic Cancer: Targets and Therapy
سال: 2014
ISSN: 1179-9889
DOI: 10.2147/blctt.s32468